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	Provedor de dados BJID (1) Autor Brandão,Lucas A.C. (1) Coelho,Antonio V.C. (1) Crovella,Sergio (1) Guimarães,Rafael L. (1) Moura,Ronald R. de (1) Palavra-chave Genetic association study (1) HIV-1 (1) Immunogenetics (1) Pharmacodynamics (1) Survival analysis (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers BJID Coelho,Antonio V.C.; Moura,Ronald R. de; Guimarães,Rafael L.; Brandão,Lucas A.C.; Crovella,Sergio. ABSTRACT Background: Antiretroviral therapy (ART) saved millions from HIV-1 infection and AIDS, but some patients do not experience adequate CD4+ T cells gain despite achieving viral suppression. The genetic component of this condition is not yet completely elucidated. Objective: To identify predictive genetic markers of immune response to ART. Methods: Case–control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls. A set of 94 selected single nucleotide polymorphisms (SNPs) involved in antiretroviral drugs pharmacodynamic pathways and immune system homeostasis were genotyped, while the remaining... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV-1; Pharmacodynamics; Immunogenetics; Genetic association study; Survival analysis. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500392 Registros recuperados: 1 Primeira ... 1 ... Última

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